Regulation of pain in experimental osteoarthritis – the impact of physical training on endogenous pro-algesic and analgesic mechanisms

Abstract: Pain is a debilitating sign of osteoarthritis and it impairs the function and quality of life. Current pharmacological and surgical treatments are unsatisfactory and produce serious adverse effects. We propose that physical training improves osteoarthritis pain by down-regulation of pro-algesic mediators and up-regulation of analgesic mediators. As an osteoarthritis model we will employ a traumatic injury of the knee in mice, while exercise will be performed using a rodent vibration device. In these conditions we will analyze the expression of various pro-algesic and analgesic mediators along the nociceptive pathways using biochemical and molecular biology methods, and investigate the functional contribution of the mediators to pain control by means of in vivo behavioral tests. Additionally, the mediators will be examined in tissue samples from patients with osteoarthritis . These studies will provide new insights into mechanisms of possible analgesic actions of vibration-based exercise in osteoarthritis  pain. By promoting the use of endogenous painkillers in response to physical training, our studies offer a potential approach for safe control of pain in osteoarthritis.


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