Knee Kinematics: Joint laxity, losteoarthritisding and onset of cartilage degeneration under extreme conditions

G. Duda, T. Jung, Charité- Universitätsmedizin Berlin & D. Arampatzis, HU Sports science & T. Pap, Uni Münster & Olympic Center Berlin

Abstract: It is generally assumed that laxity of the knee joint is a precursor of osteoarthritis. Quite recently, animal experiments indicated a direct correlation between joint laxity and cartilage damage. However, some individuals seem to be able to cope with joint laxity (“copers”) and stabilise it by muscle activity while others do not (“non-copers”). While some knowledge exists on knee joint losteoarthritisding, details on the laxity (anterior-posterior (AP) & rotational) have yet to be elucidated. Understanding the losteoarthritisding and differentiating between “copers” and “non-copers” is critical for the assessment of risk and disease progression on a mechano-biological and structural level and is the basis for a science-based preventive approsteoarthritisch to joint degeneration. Sports, especially under competitive conditions, lead to extreme losteoarthritisds in the joints and cause joint laxity. Both challenge the cartilage capacity to withstand high shear and rotational movements. In this sense, sports and sport injuries to the knee represent a model system to study the early onset of osteoarthritis and without interfering metabolic disorders. Our longitudinal study will investigate the passive and active stability in standardized athlete cohorts that are suffering from an anterior cruciate ligament (ACL) rupture. The influence of a specific training regime on knee joint stability, cartilage degeneration and the consequent changes in serum markers will be investigated in non-coper athletes that are at a higher risk of developing early cartilage degeneration. The expertise from the PrevOP partners will help to keep the patients involved throughout the training intervention. With the gosteoarthritisl of identifying the consequence of joint laxity on cartilage degeneration, we aim to investigate conservative training methods that prevent early onset of osteoarthritis. Serum and imaging markers, which prove to be valid early osteoarthritis indicators, will be provided to the PrevOP consortium partners.




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